Glucose Granulation: High Shear Mixer & Fluid Bed Dryer

The production of high-quality glucose granules requires precision, consistency, and top-tier pharmaceutical machinery. For pharmaceutical manufacturers aiming for optimal flowability and uniform particle size distribution, combining a High Shear Granulator with a Fluid Bed Dryer is the industry-standard solution.

In this comprehensive guide, we will walk you through the standard production process of glucose granules (also known as glucose powder sachets), detailing the operating parameters and technical insights that ensure mid-to-high-end production quality.

The Core Raw Materials

Before initiating the granulation process, strict formulation weighing is required. For this specific glucose granule process, the key raw materials include:

• Glucose Powder (Active ingredient)

• Maltodextrin & Corn Starch (Excipients/Binders)

• Purified Water (Granulation liquid)

Step-by-Step Production Process of Glucose Granules

Step 1: Premixing in the High Shear Granulator

The first critical step involves loading the glucose powder, maltodextrin, and corn starch into the High Shear Granulator.

• Premixing Time: 2 minutes

• Main Impeller Speed: 20 Hz

• Objective: The powerful impeller ensures the rapid and uniform blending of the dry powders, which is a prerequisite for high-quality wet granulation.

Step 2: Wet Granulation Process

Once the dry mixing is complete, the wet granulation process begins by adjusting the equipment’s operating parameters.

• Purified Water Added: 4 kg

• Water Addition Time: 30 seconds

• Objective: The rapid and precise addition of purified water, combined with the high shear action, forces the powder mixture to agglomerate and form dense, uniform wet granules.

Step 3: Vacuum Transfer to the Fluid Bed Dryer

To maintain a closed-loop, GMP-compliant production environment, the wet granules are automatically transferred.

• Material Transfer Time: 10 minutes

• Control Parameters: Adjusting fan speed and inlet air valves.

• Objective: Using a negative pressure (vacuum) conveying system, the wet materials are safely sucked into the Fluid Bed Dryer, ensuring stable fluidization from the very beginning of the transfer.

Step 4: Fluid Bed Drying

Once inside the fluid bed, the wet granules are suspended in a stream of heated air.

• Drying Time: 30 minutes

• Control Parameters: Setting precise inlet air temperature and adjusting fan speeds to maintain optimal fluidization.

• Objective: This thermodynamic process ensures gentle and even drying, preventing granule degradation while removing moisture effectively.

Step 5: Filter Bag Shaking (De-dusting)

To maintain thermodynamic efficiency during the drying process, the equipment’s filter bags must be kept clean to allow proper airflow.

• Shaking Frequency: 5 shakes every 15 seconds.

• Objective: This automated shaking prevents powder accumulation on the filters, ensuring consistent airflow and reducing drying time.

Step 6: Drying Completion

• Target Moisture Content: 4%

• Objective: The drying phase automatically concludes when the granules’ moisture content drops to 4%, yielding perfectly dried granules ready for the final sizing.

Step 7: Dry Milling & Final Sizing

The dried granules are then passed through a dry granulator (milling system).

• Objective: This final step breaks down any oversized agglomerates, guaranteeing a uniform particle size distribution. The result is a free-flowing, highly soluble glucose granule product ready for sachet packaging or further processing.

Beyond Granulation: Advancing to Premium Solid Dosage Forms

While the process above produces perfect granules for sachets, many pharmaceutical formulations require these granules to be compressed into tablets. This is where the true value of high-end manufacturing shines.

Once your High Shear Granulator and Fluid Bed Dryer have produced premium granules, the final step in creating world-class solid dosage forms is coating.

As a leading innovator in solid dosage solutions, JianPai Technology’s flagship product—the Premium Tablet Coating Machine—is highly favored by pharmaceutical plants across Europe and North America. Designed to meet the strictest FDA and EU-GMP standards, our tablet coating systems offer:

• Exceptional spray precision for uniform coating layers.

• Advanced thermodynamic designs for rapid drying.

• Complete integration with upstream granulation equipment.

Whether you are producing immediate-release, enteric-coated, or controlled-release tablets, our Tablet Coating solutions ensure your final product meets the highest international quality benchmarks.

Partner with a Top 10 Pharmaceutical Equipment Manufacturer in China

Founded in 1997, Zhejiang JianPai Technology Co., Ltd is a “National High-Tech Enterprise” supported by a dedicated team of 200 industry professionals. With decades of experience, we have proudly earned our place as a Top 10 Pharmaceutical Equipment Manufacturer in China.

We specialize in providing mid-to-high-end, turnkey solid dosage manufacturing solutions for the global market, with a strong focus on Tablet Coating Systems, High Shear Mixers, and Fluid Bed Dryers.

Ready to upgrade your pharmaceutical production line?
Contact JianPai Technology Today to consult with our engineering experts and discover machinery built for global excellence.