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Epalrestat is a key medication for treating diabetic neuropathy. Its active ingredient is sensitive to stomach acid, so enteric coating is essential to protect it and ensure it releases in the intestines for optimal absorption.
The enteric coating serves three critical functions:
Drug Protection: Shields epalrestat from gastric acid, preserving its effectiveness.
Reduced Irritation: Prevents direct contact with the stomach lining.
Targeted Release: Ensures the drug dissolves only in the intestines’ neutral/alkaline environment.
3.1 Preparation Before Coating
| Preparation Item | Specific Requirements |
| Equipment Check | Inspect the コーティング装置 (e.g., Jianpai’s machine) to ensure all parts are clean and functional. |
| Material & Tablet Prep | – Coating materials: Select acid-resistant, enteric polymers.- Tablets: Pre-screen cores to remove defects and dry them to 2-3% moisture. |
3.2 Key Steps in the Coating Process
Coating Material Preparation: Mix the enteric polymer, plasticizer, and colorant (if needed) with purified water to form a 10-15% solution.
Actual Coating Operation:
Load core tablets into the rotating drum (10-15 rpm).
Adjust the spray gun (15-20 cm from the tablet bed) and spray at 5-10 mL/min.
Maintain drum temperature at 40-45°C for real-time drying.
Repeat until the coating reaches the desired thickness (5-10% weight gain).
Jianpai’s high-efficiency コーティングマシン offers significant advantages:
| Advantage | 説明 |
| Superior Sealing | A double-layer silicone seal prevents solution leakage and contamination. |
| Advanced Spray Gun | Features anti-clogging and anti-dripping design for a smooth, uniform coating. |
| Intelligent Operation | Touchscreen control with dynamic parameter display and process data storage. |
| Energy-Saving Design | Variable-frequency pump and adjustable exhaust save energy while ensuring quality. |
Results and Video Display
Using Jianpai’s coating machine produced excellent results:
Weight increased by 10% (meets coating standards).
Loss rate decreased by 5%, significantly lower than the industry average.
Please watch our video to see the perfect coating of this type of tablets using Jianpai’s high-efficiency coating machine. The enteric-coated epalrestat tablets have been completed. The weight has increased by 10% and the loss has decreased by 5%.
The coating of enteric tablets demands precise control of equipment, materials, and parameters. Jianpai’s Coating Equipment simplifies this process, making it suitable for novices while improving product quality and production efficiency.
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