{"id":5030,"date":"2026-02-06T14:33:10","date_gmt":"2026-02-06T06:33:10","guid":{"rendered":"https:\/\/www.jianpaitech.com\/?post_type=blog&#038;p=5030"},"modified":"2026-02-06T14:33:10","modified_gmt":"2026-02-06T06:33:10","slug":"high-shear-mixer-granulation-how-to-determine-the-perfect-end-point","status":"publish","type":"blog","link":"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/","title":{"rendered":"Granula\u00e7\u00e3o de misturador de alto cisalhamento: como determinar o ponto final perfeito?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u00cdndice<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar \u00edndice de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Alternar<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Introduction\" >Introdu\u00e7\u00e3o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#What_is_the_Granulation_End-Point\" >Qual \u00e9 o ponto final da granula\u00e7\u00e3o?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Why_is_the_Granulation_End-Point_So_Critical\" >Por que o ponto final da granula\u00e7\u00e3o \u00e9 t\u00e3o cr\u00edtico?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Key_Variables_Influencing_the_End-Point\" >Principais vari\u00e1veis \u200b\u200bque influenciam o ponto final<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#4_Practical_Methods_to_Determine_the_End-Point_Comparison\" >4 m\u00e9todos pr\u00e1ticos para determinar o ponto final (compara\u00e7\u00e3o)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#The_Traditional_Approach_Time_Manual_Squeeze\" >A abordagem tradicional: tempo e compress\u00e3o manual<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Power_Consumption_Amperage_The_Industry_Standard\" >Consumo de energia\/amperagem (o padr\u00e3o da ind\u00fastria)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Torque_Monitoring_The_Precision_Choice\" >Monitoramento de Torque (A Escolha de Precis\u00e3o)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Advanced_Process_Analytical_Technology_PAT\" >Tecnologia Anal\u00edtica de Processo Avan\u00e7ada (PAT)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Comparison_Table_Which_Method_Fits_Your_Production\" >Tabela Comparativa: Qual M\u00e9todo se Adapta \u00e0 Sua Produ\u00e7\u00e3o?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#How_Jianpais_Rapid_Mixer_Granulator_Ensures_Consistency\" >Como o granulador misturador r\u00e1pido da Jianpai garante consist\u00eancia<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.jianpaitech.com\/pt\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Conclusion\" >Conclus\u00e3o<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Introduction\"><\/span><span class=\"ng-star-inserted\">Introdu\u00e7\u00e3o<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Na fabrica\u00e7\u00e3o farmac\u00eautica, a consist\u00eancia \u00e9 fundamental. Ao produzir comprimidos, o\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/pt\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granula\u00e7\u00e3o de misturador de alto cisalhamento<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0processo \u00e9 muitas vezes a etapa mais cr\u00edtica. Ele determina a fluidez, compressibilidade e perfil de dissolu\u00e7\u00e3o da sua forma farmac\u00eautica final.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">No entanto, uma quest\u00e3o atormenta tanto os operadores como os cientistas de formula\u00e7\u00e3o:\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">\u201cQuando exatamente a granula\u00e7\u00e3o termina?\u201d<\/span><\/strong><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pare muito cedo e voc\u00ea ter\u00e1 multas que n\u00e3o ser\u00e3o comprimidas. Pare tarde demais e voc\u00ea ter\u00e1 caro\u00e7os duros e grandes que n\u00e3o se dissolvem. Este \u201cponto ideal\u201d \u00e9 chamado de\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Ponto final de granula\u00e7\u00e3o<\/span><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Neste guia, iremos al\u00e9m das suposi\u00e7\u00f5es. Exploraremos a ci\u00eancia por tr\u00e1s da detec\u00e7\u00e3o de endpoint e compararemos os m\u00e9todos tradicionais com as tecnologias modernas usadas no avan\u00e7ado da Jianpai.\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/pt\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulador Misturador R\u00e1pido<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0(RMG).<\/span><\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft size-full wp-image-4638\" src=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator.jpg?quality=85&strip=all\" alt=\"\" width=\"675\" height=\"408\" srcset=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator.jpg?quality=85&strip=all 675w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator-300x181.jpg?quality=85&strip=all 300w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator-18x12.jpg?quality=85&strip=all 18w\" sizes=\"(max-width: 675px) 100vw, 675px\" \/><\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"What_is_the_Granulation_End-Point\"><\/span><span class=\"ng-star-inserted\">Qual \u00e9 o ponto final da granula\u00e7\u00e3o?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">O\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Ponto final de granula\u00e7\u00e3o<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0\u00e9 o momento preciso durante a fase de mistura \u00famida quando os gr\u00e2nulos atingiram as propriedades desejadas:<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Distribui\u00e7\u00e3o alvo do tamanho das part\u00edculas:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Nem muito empoeirado, nem muito irregular.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Densidade ideal:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Garante o preenchimento uniforme da matriz na prensa de comprimidos.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Porosidade Correta:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Afeta a distribui\u00e7\u00e3o do ligante e a resist\u00eancia dos gr\u00e2nulos.<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Em um\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/pt\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">M\u00e1quina granuladora \u00famida<\/span><\/a><\/strong><span class=\"ng-star-inserted\">, este momento ocorre quando o aglutinante l\u00edquido umedeceu completamente o p\u00f3 e formou pontes s\u00f3lidas, mas antes dos gr\u00e2nulos se tornarem uma pasta inutiliz\u00e1vel.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Why_is_the_Granulation_End-Point_So_Critical\"><\/span><span class=\"ng-star-inserted\">Por que o ponto final da granula\u00e7\u00e3o \u00e9 t\u00e3o cr\u00edtico?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Perder o ponto final tem um efeito domin\u00f3 em toda a sua linha de produ\u00e7\u00e3o:<\/span><\/p>\n<ol class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Defeitos do tablet:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0O umedecimento excessivo leva a \u201cpegar\u201d e \u201cgrudar\u201d no pun\u00e7\u00e3o da prensa para comprimidos.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Falha na dissolu\u00e7\u00e3o:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Part\u00edculas duras e supergranuladas podem falhar nos testes de dissolu\u00e7\u00e3o no CQ.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Perda de rendimento:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Lotes subgranulados geram finos excessivos, que s\u00e3o desperdi\u00e7ados na\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/pt\/product_category\/fluid-bed-dryer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Secador de leito fluidizado<\/span><\/a><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Variabilidade lote a lote:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Se o Operador A parar aos 3 minutos e o Operador B parar aos 4 minutos, voc\u00ea obter\u00e1 dois produtos diferentes.<\/span><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Key_Variables_Influencing_the_End-Point\"><\/span><span class=\"ng-star-inserted\">Principais vari\u00e1veis \u200b\u200bque influenciam o ponto final<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Antes de escolher um m\u00e9todo de detec\u00e7\u00e3o, entenda que o ponto final \u00e9 um alvo m\u00f3vel influenciado por:<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Taxa de adi\u00e7\u00e3o de fich\u00e1rio:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0A pulveriza\u00e7\u00e3o muito r\u00e1pida causa umedecimento excessivo local.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Velocidade do impulsor:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Velocidades mais altas adicionam mais energia mec\u00e2nica, atingindo o ponto final mais rapidamente.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Variabilidade da mat\u00e9ria-prima:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Uma ligeira altera\u00e7\u00e3o no tamanho das part\u00edculas do seu API ou excipientes pode alterar o tempo de mistura necess\u00e1rio.<\/span><\/p>\n<\/li>\n<\/ul>\n<blockquote class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Dica profissional: um robusto\u00a0<strong class=\"ng-star-inserted\">Processo de granula\u00e7\u00e3o de alto cisalhamento<\/strong>\u00a0depende do controle dessas vari\u00e1veis \u200b\u200bpor meio de um sistema de gerenciamento de receitas PLC, um recurso padr\u00e3o nos RMGs Jianpai.<\/span><\/p>\n<p>&nbsp;<\/p><\/blockquote>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"4_Practical_Methods_to_Determine_the_End-Point_Comparison\"><\/span><span class=\"ng-star-inserted\">4 m\u00e9todos pr\u00e1ticos para determinar o ponto final (compara\u00e7\u00e3o)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Como voc\u00ea sabe quando parar? Aqui est\u00e3o os quatro m\u00e9todos mais comuns usados \u200b\u200bna ind\u00fastria, classificados do b\u00e1sico ao avan\u00e7ado.<\/span><\/p>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"The_Traditional_Approach_Time_Manual_Squeeze\"><\/span><span class=\"ng-star-inserted\">A abordagem tradicional: tempo e compress\u00e3o manual<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Deixe a batedeira funcionar por um tempo fixo (por exemplo, 5 minutos) e depois pare. O operador abre a tampa, pega um punhado de gr\u00e2nulos e os espreme (o \u201cTeste da Banana\u201d). Se mantiver a forma, mas quebrar com a press\u00e3o do polegar, est\u00e1 feito.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pr\u00f3s:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Custo zero; nenhuma tecnologia necess\u00e1ria.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Altamente subjetivo. \u201cAperto do Operador A\u201d \u00e9 diferente de \u201cAperto do Operador B\u201d. N\u00e3o \u00e9 compat\u00edvel com GMP para medicamentos cr\u00edticos.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Power_Consumption_Amperage_The_Industry_Standard\"><\/span><span class=\"ng-star-inserted\">Consumo de energia\/amperagem (o padr\u00e3o da ind\u00fastria)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0\u00c0 medida que os gr\u00e2nulos se formam e se densificam, a resist\u00eancia nas p\u00e1s do impulsor aumenta. Isto coloca uma carga maior no motor, fazendo com que o\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Amperagem (Amp)<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0lendo para aumentar. Voc\u00ea define um limite alvo de Amp (por exemplo, parar quando o motor atingir 25 Amps).<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pr\u00f3s:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Barato para implementar; amplamente compreendido.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0A efici\u00eancia do motor, a tens\u00e3o da correia e o desgaste das engrenagens podem afetar as leituras de Amp. Ele mede o\u00a0<\/span><span class=\"ng-star-inserted\">motor<\/span><span class=\"ng-star-inserted\">\u00a0esfor\u00e7o, n\u00e3o o\u00a0<\/span><span class=\"ng-star-inserted\">gr\u00e2nulos'<\/span><span class=\"ng-star-inserted\">\u00a0estado diretamente.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Torque_Monitoring_The_Precision_Choice\"><\/span><span class=\"ng-star-inserted\">Monitoramento de Torque (A Escolha de Precis\u00e3o)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Isto mede o real\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Torque (Nm)<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0exercido no eixo do impulsor.<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Torque indireto:<\/span><span class=\"ng-star-inserted\">\u00a0Calculado a partir da corrente do inversor VFD.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Torque Direto:<\/span><span class=\"ng-star-inserted\">\u00a0Medido atrav\u00e9s de um sensor de extens\u00f4metro diretamente no eixo.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pr\u00f3s:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Muito mais sens\u00edvel que a Amperagem. Ele se correlaciona diretamente com a densidade dos gr\u00e2nulos e a reologia.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Sensores de torque direto s\u00e3o caros. O torque indireto (calculado) \u00e9 um bom equil\u00edbrio para a maioria\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granula\u00e7\u00e3o RMG<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0processos.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Advanced_Process_Analytical_Technology_PAT\"><\/span><span class=\"ng-star-inserted\">Tecnologia Anal\u00edtica de Processo Avan\u00e7ada (PAT)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Usando sensores de emiss\u00e3o ac\u00fastica (ouvindo o som dos gr\u00e2nulos atingindo a parede) ou sondas NIR (infravermelho pr\u00f3ximo) para medir a umidade em tempo real.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pr\u00f3s:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0O \u201cSanto Graal\u201d da precis\u00e3o.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Extremamente caro; dif\u00edcil de calibrar e validar.<\/span><\/p>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Comparison_Table_Which_Method_Fits_Your_Production\"><\/span><span class=\"ng-star-inserted\">Tabela Comparativa: Qual M\u00e9todo se Adapta \u00e0 Sua Produ\u00e7\u00e3o?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"table-container ng-star-inserted\">\n<table>\n<tbody>\n<tr class=\"table-header ng-star-inserted\">\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Precis\u00e3o<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Custo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Conformidade com BPF<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Melhor para\u2026<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Aperto Manual<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Baixo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Baixo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pobre<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">P&amp;D, produtos aliment\u00edcios simples<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Baseado no tempo<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9dio<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Baixo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Moderado<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Processos validados e est\u00e1veis<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pot\u00eancia (Amperes)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Alto<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9dio<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Bom<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Farmac\u00eautico Gen\u00e9rico Padr\u00e3o<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Torque (Nm)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Muito alto<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Alto<\/span><\/td>\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Excelente<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Drogas Complexas\/Potentes<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">PAT (NIR\/Ac\u00fastico)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Extremo<\/span><\/td>\n<td class=\"ng-star-inserted\">\n<pre><code class=\"rendered\"><\/code><\/pre>\n<\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Excelente<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Novos medicamentos de alto valor<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<\/div>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"How_Jianpais_Rapid_Mixer_Granulator_Ensures_Consistency\"><\/span><span class=\"ng-star-inserted\">Como o granulador misturador r\u00e1pido da Jianpai garante consist\u00eancia<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">No\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Jianpai<\/span><\/strong><span class=\"ng-star-inserted\">, entendemos que a reprodutibilidade \u00e9 o maior desafio em\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granula\u00e7\u00e3o de misturador de alto cisalhamento<\/span><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Nosso\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/pt\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulador Misturador R\u00e1pido<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0s\u00e9rie \u00e9 projetada para eliminar o \u201cfator humano\u201d:<\/span><\/p>\n<ol class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">L\u00f3gica de controle duplo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Nosso PLC Siemens permite que voc\u00ea defina o ponto final com base em\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Tempo OU Pot\u00eancia\/Torque<\/span><\/strong><span class=\"ng-star-inserted\">. Por exemplo:\u00a0<\/span><span class=\"ng-star-inserted\">\u201cMisture por 3 minutos E at\u00e9 que o torque atinja 15 Nm.\u201d<\/span><span class=\"ng-star-inserted\">\u00a0Esta l\u00f3gica \u201cAND\u201d garante seguran\u00e7a.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Tend\u00eancias em tempo real:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0A HMI exibe um gr\u00e1fico ao vivo do consumo de pot\u00eancia\/torque, permitindo que os cientistas da formula\u00e7\u00e3o visualizem as fases de granula\u00e7\u00e3o (umedecimento -&gt; nuclea\u00e7\u00e3o -&gt; plat\u00f4).<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Geometria Escal\u00e1vel:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Garantimos que a correla\u00e7\u00e3o entre Torque e Qualidade dos Gr\u00e2nulos permane\u00e7a consistente desde nossos modelos de P&amp;D de Laborat\u00f3rio at\u00e9 nossos modelos de Produ\u00e7\u00e3o.<\/span><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span><span class=\"ng-star-inserted\">Conclus\u00e3o<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Determinando o\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Ponto final de granula\u00e7\u00e3o<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0n\u00e3o \u00e9 mais um jogo de adivinha\u00e7\u00e3o. Embora o m\u00e9todo \u201cHand Squeeze\u201d tenha nos servido bem no passado, os padr\u00f5es modernos de GMP exigem decis\u00f5es baseadas em dados.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Para a maioria dos fabricantes farmac\u00eauticos,\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Consumo de energia (amperagem) ou monitoramento de torque<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0oferece o melhor equil\u00edbrio entre precis\u00e3o e custo. Ao investir em um\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/pt\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">M\u00e1quina granuladora \u00famida<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0equipado com sistemas de monitoramento avan\u00e7ados, voc\u00ea garante que cada lote seja compactado perfeitamente em tablets de alta qualidade.<\/span><\/p>\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pronto para atualizar seu processo de granula\u00e7\u00e3o?<\/span><\/strong><br class=\"ng-star-inserted\" \/><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contato Jianpai<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0hoje para discutir nosso inteligente\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granuladores Misturadores R\u00e1pidos<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0e como eles podem resolver seus problemas de inconsist\u00eancia de lote.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Introdu\u00e7\u00e3o Na fabrica\u00e7\u00e3o farmac\u00eautica, a consist\u00eancia \u00e9 fundamental. Ao produzir comprimidos, o processo de granula\u00e7\u00e3o com misturador de alto cisalhamento costuma ser a etapa mais cr\u00edtica. Ele determina a fluidez, compressibilidade e perfil de dissolu\u00e7\u00e3o da sua forma farmac\u00eautica final. No entanto, uma pergunta atormenta tanto os operadores quanto os cientistas de formula\u00e7\u00e3o:\u00a0\u201cQuando exatamente a granula\u00e7\u00e3o termina?\u201d Pare muito cedo e voc\u00ea ter\u00e1 multas que [\u2026]<\/p>","protected":false},"featured_media":5031,"template":"","meta":{"_acf_changed":false,"footnotes":""},"blog_category":[16],"class_list":["post-5030","blog","type-blog","status-publish","has-post-thumbnail","hentry","blog_category-industry-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/blog\/5030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/types\/blog"}],"version-history":[{"count":1,"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/blog\/5030\/revisions"}],"predecessor-version":[{"id":5032,"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/blog\/5030\/revisions\/5032"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/media\/5031"}],"wp:attachment":[{"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/media?parent=5030"}],"wp:term":[{"taxonomy":"blog_category","embeddable":true,"href":"https:\/\/www.jianpaitech.com\/pt\/wp-json\/wp\/v2\/blog_category?post=5030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}