{"id":4375,"date":"2025-08-20T10:15:52","date_gmt":"2025-08-20T02:15:52","guid":{"rendered":"https:\/\/www.jianpaitech.com\/?post_type=blog&#038;p=4375"},"modified":"2025-08-20T10:15:52","modified_gmt":"2025-08-20T02:15:52","slug":"how-to-make-pills","status":"publish","type":"blog","link":"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/","title":{"rendered":"\u4e38\u85ac\u306e\u4f5c\u308a\u65b9\u306f\uff1f"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u30c6\u30fc\u30d6\u30eb\u3092\u5207\u308a\u66ff\u3048\u307e\u3059\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">\u30c8\u30b0\u30eb<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#1_Importance_of_Pill_Manufacturing\" >1.\u9320\u5264\u88fd\u9020\u306e\u91cd\u8981\u6027<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#11_Two_Core_Pill_Manufacturing_Methods\" >1.1 2\u3064\u306e\u30b3\u30a2\u30d4\u30eb\u88fd\u9020\u65b9\u6cd5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#2_Key_Ingredients_in_Tablet_Manufacturing\" >2\u3002\u30bf\u30d6\u30ec\u30c3\u30c8\u88fd\u9020\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u6210\u5206<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#21_Active_Pharmaceutical_Ingredient_API\" >2.1\u30a2\u30af\u30c6\u30a3\u30d6\u306a\u533b\u85ac\u54c1\u6210\u5206\uff08API\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#22_Pharmaceutical_Excipients\" >2.2\u533b\u85ac\u54c1\u8ce6\u5f62\u5264<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#3_Direct_Compression_DC\" >3\u3002\u76f4\u63a5\u5727\u7e2e\uff08DC\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#31_Pill_Manufacturing_Process\" >3.1\u9320\u5264\u88fd\u9020\u30d7\u30ed\u30bb\u30b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#32_Advantages_of_Direct_Compression\" >3.2\u76f4\u63a5\u5727\u7e2e\u306e\u5229\u70b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#33_Challenges_in_Direct_Compression\" >3.3\u76f4\u63a5\u5727\u7e2e\u306b\u304a\u3051\u308b\u8ab2\u984c<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#4_Granulation\" >4\u3002\u9846\u7c92<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#41_Definition\" >4.1\u5b9a\u7fa9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#42_Why_Use_It\" >4.2\u306a\u305c\u305d\u308c\u3092\u4f7f\u7528\u3059\u308b\u306e\u3067\u3059\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#43_Dry_Granulation\" >4.3\u4e7e\u71e5\u9846\u7c92<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#44_Wet_Granulation\" >4.4\u6e7f\u6f64\u9846\u7c92<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#5_Comparison_Table_of_Pill_Manufacturing_Methods\" >5\u3002\u4e38\u85ac\u88fd\u9020\u65b9\u6cd5\u306e\u6bd4\u8f03\u8868<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.jianpaitech.com\/ja\/blog\/how-to-make-pills\/#6_Conclusion\" >6\u3002\u7d50\u8ad6<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"1_Importance_of_Pill_Manufacturing\"><\/span>1.\u9320\u5264\u88fd\u9020\u306e\u91cd\u8981\u6027<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u4e38\u85ac\u3001\u307e\u305f\u306f\u533b\u85ac\u54c1\u9320\u5264\u306f\u3001\u4e16\u754c\u3067\u6700\u3082\u4e00\u822c\u7684\u306a\u85ac\u7269\u9001\u9054\u30b7\u30b9\u30c6\u30e0\u306e1\u3064\u3067\u3059\u3002\u305d\u308c\u3089\u306f\u4fbf\u5229\u3067\u30dd\u30fc\u30bf\u30d6\u30eb\u3067\u3042\u308a\u3001\u6b63\u78ba\u306a\u6295\u4e0e\u3092\u53ef\u80fd\u306b\u3057\u3001\u305d\u308c\u3089\u3092\u790e\u77f3\u306b\u3057\u307e\u3059 <strong>\u88fd\u85ac\u30bf\u30d6\u30ec\u30c3\u30c8\u88fd\u9020<\/strong>.<\/p>\n<p>\u306e\u54c1\u8cea <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u751f\u7523<\/strong>\u00a0\u85ac\u7269\u306e\u5b89\u5168\u6027\u3001\u5b89\u5b9a\u6027\u3001\u60a3\u8005\u306e\u8ee2\u5e30\u306b\u76f4\u63a5\u5f71\u97ff\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u7406\u89e3\u3057\u307e\u3059 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u88fd\u9020\u624b\u9806<\/strong>\u00a0\u95a2\u4e0e\u3059\u308b\u5c02\u9580\u5bb6\u3068\u4f01\u696d\u306e\u4e21\u65b9\u306b\u3068\u3063\u3066\u4e0d\u53ef\u6b20\u3067\u3059 <strong>\u85ac\u7269\u306e\u88fd\u5264<\/strong>.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"11_Two_Core_Pill_Manufacturing_Methods\"><\/span>1.1 2\u3064\u306e\u30b3\u30a2\u30d4\u30eb\u88fd\u9020\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e83\u304f\u63a1\u7528\u3055\u308c\u3066\u3044\u308b2\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3042\u308a\u307e\u3059 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u88fd\u9020<\/strong>:<\/p>\n<ul>\n<li><strong>\u76f4\u63a5\u5727\u7e2e\uff08DC\uff09\uff1a<\/strong>\u30b7\u30f3\u30d7\u30eb\u3067\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u304c\u9ad8\u304f\u3001\u6eb6\u5a92\u306a\u3057\u306e\u65b9\u6cd5\u3002<\/li>\n<li><strong>\u9846\u7c92\uff1a<\/strong>API\u307e\u305f\u306f\u8ce6\u5f62\u5264\u306bDC\u306b\u9069\u3057\u305f\u7279\u6027\u304c\u306a\u3044\u5834\u5408\u306b\u4f7f\u7528\u3055\u308c\u308b\u7c92\u5b50\u5f37\u5316\u6cd5\u3002<\/li>\n<\/ul>\n<p>\u305d\u308c\u305e\u308c\u306b\u306f\u5229\u70b9\u3068\u8ab2\u984c\u304c\u3042\u308a\u3001\u9078\u629e\u306fAPI\u30d7\u30ed\u30d1\u30c6\u30a3\u3001\u52b1\u8d77\u5177\u306e\u6027\u80fd\u3001\u304a\u3088\u3073\u5168\u4f53\u306b\u4f9d\u5b58\u3057\u307e\u3059 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u7d44\u6210<\/strong>.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft size-full wp-image-4376\" src=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/poisoning-pill-bottle.jpg?quality=85&strip=all\" alt=\"\" width=\"1500\" height=\"1000\" srcset=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/poisoning-pill-bottle.jpg?quality=85&strip=all 1500w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/poisoning-pill-bottle-300x200.jpg?quality=85&strip=all 300w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/poisoning-pill-bottle-1024x683.jpg?quality=85&strip=all 1024w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/poisoning-pill-bottle-768x512.jpg?quality=85&strip=all 768w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/poisoning-pill-bottle-18x12.jpg?quality=85&strip=all 18w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"2_Key_Ingredients_in_Tablet_Manufacturing\"><\/span>2\u3002\u30bf\u30d6\u30ec\u30c3\u30c8\u88fd\u9020\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u6210\u5206<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5165\u308b\u524d\u306b <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u4f5c\u6210\u624b\u9806<\/strong>\u3001\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u30b3\u30a2\u30b3\u30f3\u30dd\u30fc\u30cd\u30f3\u30c8\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"21_Active_Pharmaceutical_Ingredient_API\"><\/span>2.1\u30a2\u30af\u30c6\u30a3\u30d6\u306a\u533b\u85ac\u54c1\u6210\u5206\uff08API\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p> <strong>API<\/strong>\u00a0\u6cbb\u7642\u6d3b\u52d5\u3092\u63d0\u4f9b\u3059\u308b\u4e3b\u306a\u6210\u5206\u3067\u3059\u3002 API\u306f\u3001\u7528\u91cf\u3001\u6eb6\u89e3\u5ea6\u3001\u6d41\u52d5\u6027\u3001\u5b89\u5b9a\u6027\u304c\u5927\u304d\u304f\u7570\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u3001\u3053\u308c\u306f\u76f4\u63a5\u5f71\u97ff\u3057\u307e\u3059 <strong>\u4e38\u85ac\u88fd\u9020\u30d7\u30ed\u30bb\u30b9<\/strong>\u00a0\u9078\u3070\u308c\u305f\u3002<\/p>\n<ul>\n<li><strong>\u4f4e\u7528\u91cfAPI\uff1a<\/strong>\u5206\u96e2\u306e\u30ea\u30b9\u30af\u3068\u5747\u4e00\u6027\u304c\u4f4e\u3044\u3002<\/li>\n<li><strong>\u9ad8\u7528\u91cfAPI\uff1a<\/strong>\u30d5\u30a3\u30e9\u30fc\u306f\u5727\u7e2e\u7387\u3092\u9069\u5207\u306b\u6539\u5584\u3057\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u3001\u9846\u7c92\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"22_Pharmaceutical_Excipients\"><\/span>2.2\u533b\u85ac\u54c1\u8ce6\u5f62\u5264<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8ce6\u5f62\u5264\u306f\u3001\u306e\u975e\u30a2\u30af\u30c6\u30a3\u30d6\u6210\u5206\u3067\u3059 <strong>\u88fd\u9020\u30bf\u30d6\u30ec\u30c3\u30c8<\/strong>\u00a0\u30d7\u30ed\u30bb\u30b9\u3002\u30bf\u30d6\u30ec\u30c3\u30c8\u3092\u5727\u7e2e\u3001\u4fdd\u5b58\u3001\u52b9\u679c\u7684\u306b\u63a1\u53d6\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u30ab\u30c6\u30b4\u30ea\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n<ul>\n<li><strong>\u30d5\u30a3\u30e9\u30fc\/\u5e0c\u91c8\u5264<\/strong>\uff08\u4f8b\uff1a\u30e9\u30af\u30c8\u30fc\u30b9\u3001MCC\u3001\u30de\u30f3\u30cb\u30c8\u30fc\u30eb\uff09 - \u30d0\u30eb\u30af\u3092\u8ffd\u52a0\u3057\u307e\u3059\u3002<\/li>\n<li><strong>\u30d0\u30a4\u30f3\u30c0\u30fc<\/strong>\uff08\u4f8b\uff1aPVP\u3001\u6fb1\u7c89\uff09 - \u51dd\u96c6\u3092\u6539\u5584\u3057\u307e\u3059\u3002<\/li>\n<li><strong>\u5d29\u58ca\u5264<\/strong>- \u6442\u53d6\u5f8c\u306b\u30bf\u30d6\u30ec\u30c3\u30c8\u304c\u30d0\u30e9\u30d0\u30e9\u306b\u306a\u308b\u3088\u3046\u306b\u3057\u307e\u3059\u3002<\/li>\n<li><strong>\u6f64\u6ed1\u5264<\/strong>\uff08\u4f8b\u3048\u3070\u3001\u30b9\u30c6\u30a2\u30ec\u30fc\u30c8\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\uff09 - \u56fa\u57f7\u3092\u9632\u304e\u307e\u3059\u3002<\/li>\n<li><strong>\u30b3\u30fc\u30c6\u30a3\u30f3\u30b0<\/strong>- \u5b89\u5b9a\u6027\u3001\u5473\u899a\u30de\u30b9\u30ad\u30f3\u30b0\u3001\u60a3\u8005\u306e\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3092\u5f37\u5316\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>\u4e00\u7dd2\u306b\u3001API\u3068\u8ce6\u5f62\u5264\u304c\u69cb\u6210\u3055\u308c\u307e\u3059 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u7d44\u6210<\/strong>\u3001\u305d\u308c\u304c\u3059\u3079\u3066\u306e\u57fa\u76e4\u3067\u3059 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u751f\u7523<\/strong>\u00a0\u6226\u7565\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"3_Direct_Compression_DC\"><\/span>3\u3002\u76f4\u63a5\u5727\u7e2e\uff08DC\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"31_Pill_Manufacturing_Process\"><\/span>3.1\u9320\u5264\u88fd\u9020\u30d7\u30ed\u30bb\u30b9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p> <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u4f5c\u6210\u624b\u9806<\/strong>\u00a0DC\u306b\u306f2\u3064\u306e\u30b9\u30c6\u30c3\u30d7\u306e\u307f\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n<p><strong>\u30d6\u30ec\u30f3\u30c9\uff1a<\/strong>\u00a0API\u306f\u3001\u826f\u597d\u306a\u6d41\u308c\u3068\u5727\u7e2e\u7387\u306e\u305f\u3081\u306b\u8a2d\u8a08\u3055\u308c\u305f\u8ce6\u5f62\u5264\u3068\u6df7\u5408\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u5727\u7e2e\uff1a<\/strong>\u00a0\u30d1\u30a6\u30c0\u30fc\u30d6\u30ec\u30f3\u30c9\u306f\u3001\u30bf\u30d6\u30ec\u30c3\u30c8\u30d7\u30ec\u30b9\u3092\u4f7f\u7528\u3057\u3066\u30bf\u30d6\u30ec\u30c3\u30c8\u306b\u76f4\u63a5\u5727\u7e2e\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"32_Advantages_of_Direct_Compression\"><\/span>3.2\u76f4\u63a5\u5727\u7e2e\u306e\u5229\u70b9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\u6700\u5c0f\u9650 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u88fd\u9020\u624b\u9806<\/strong>\u2192\u3088\u308a\u9ad8\u901f\u3067\u5b89\u4fa1\u306a\u751f\u7523\u3002<\/li>\n<li>\u6eb6\u5a92\u306f\u3042\u308a\u307e\u305b\u3093\u2192\u74b0\u5883\u306b\u3084\u3055\u3057\u304f\u3066\u5b89\u5168\u3067\u3059\u3002<\/li>\n<li>API\u306b\u512a\u3057\u3044\u2192\u6e7f\u6c17\u306b\u654f\u611f\u306a\u85ac\u5264\u307e\u305f\u306f\u71b1\u611f\u53d7\u6027\u85ac\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<li>\u3068\u4e92\u63db\u6027\u304c\u3042\u308a\u307e\u3059 <strong>\u7d99\u7d9a\u7684\u306a\u88fd\u9020<\/strong>.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"33_Challenges_in_Direct_Compression\"><\/span>3.3\u76f4\u63a5\u5727\u7e2e\u306b\u304a\u3051\u308b\u8ab2\u984c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\u5206\u96e2\u306b\u3088\u308b\u4f4e\u7528\u91cfAPI\u306e\u5747\u4e00\u6027\u306e\u554f\u984c\u3002<\/li>\n<li>\u9ad8\u7528\u91cfAPI\u306f\u3001\u6d41\u308c\/\u5727\u7e2e\u7387\u304c\u4f4e\u3044\u3053\u3068\u306b\u82e6\u3057\u3080\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<li>\u7279\u6b8a\u306a\u8ce6\u5f62\u5264\uff08DC\u30b0\u30ec\u30fc\u30c9\uff09\u3078\u306e\u4f9d\u5b58\u2192\u3088\u308a\u9ad8\u3044\u539f\u6750\u6599\u30b3\u30b9\u30c8\u3002<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"4_Granulation\"><\/span>4\u3002\u9846\u7c92<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"41_Definition\"><\/span>4.1\u5b9a\u7fa9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u9846\u7c92\u306f\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u3059 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u751f\u7523<\/strong>\u00a0\u7c89\u672b\u304c\u5927\u304d\u304f\u81ea\u7531\u306b\u6d41\u308c\u308b\u9846\u7c92\u306b\u5909\u63db\u3055\u308c\u3001\u5747\u4e00\u6027\u3068\u5727\u7e2e\u7387\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"42_Why_Use_It\"><\/span>4.2\u306a\u305c\u305d\u308c\u3092\u4f7f\u7528\u3059\u308b\u306e\u3067\u3059\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>API\u307e\u305f\u306f\u8ce6\u5f62\u5264\u306bDC\u306b\u5fc5\u8981\u306a\u7269\u7406\u7684\u7279\u6027\u304c\u306a\u3044\u5834\u5408\u3001\u8089\u82bd\u7d44\u304c\u5fc5\u8981\u3067\u3059\u3002\u6539\u5584\u3057\u307e\u3059\uff1a<\/p>\n<ul>\n<li>\u30d1\u30a6\u30c0\u30fc\u30d5\u30ed\u30fc\u3002<\/li>\n<li>\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u5f37\u5ea6\u3002<\/li>\n<li>\u306e\u5747\u4e00\u6027 <strong>\u85ac\u7269\u306e\u88fd\u5264<\/strong>.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"43_Dry_Granulation\"><\/span>4.3\u4e7e\u71e5\u9846\u7c92<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li><strong>\u30d7\u30ed\u30bb\u30b9\uff1a<\/strong>\u30ca\u30e1\u30af\u30b8\u307e\u305f\u306f\u30b7\u30fc\u30c8\u3078\u306e\u7c89\u672b\u306e\u6a5f\u68b0\u7684\u5727\u7e2e\u3001\u7d9a\u3044\u3066\u9846\u7c92\u306b\u7c89\u7815\u3057\u307e\u3059\u3002<\/li>\n<li><strong>\u30c6\u30af\u30cb\u30c3\u30af\uff1a<\/strong>\u30b9\u30e9\u30c3\u30ae\u30f3\u30b0\u3068\u30ed\u30fc\u30e9\u30fc\u5727\u7e2e\u3002<\/li>\n<li><strong>\u6700\u9069\uff1a<\/strong>\u71b1\u3068\u6c34\u5206\u306b\u654f\u611f\u306aAPI\u3002<\/li>\n<li><strong>\u9577\u6240\uff1a<\/strong>\u6eb6\u5a92\u306a\u3057\u3001\u3088\u308a\u77ed\u3044\u30d7\u30ed\u30bb\u30b9\u3001\u8cbb\u7528\u5bfe\u52b9\u679c\u3002<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"44_Wet_Granulation\"><\/span>4.4\u6e7f\u6f64\u9846\u7c92<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li><strong>\u30d7\u30ed\u30bb\u30b9\uff1a<\/strong>\u30d0\u30a4\u30f3\u30c0\u30fc\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u3092\u51dd\u96c6\u7c89\u672b\u306b\u4f7f\u7528\u3057\u3001\u305d\u308c\u306b\u7d9a\u3044\u3066\u4e7e\u71e5\u3068\u30b5\u30a4\u30b8\u30f3\u30b0\u304c\u7d9a\u304d\u307e\u3059\u3002<\/li>\n<li><strong>\u30c6\u30af\u30cb\u30c3\u30af\uff1a<\/strong>\u9ad8\u305b\u3093\u65ad\u3001\u53cc\u5b50\u306e\u306d\u3058\u308a\u3001\u6db2\u4f53\u5c64\u9846\u7c92\u3002<\/li>\n<li><strong>\u6700\u9069\uff1a<\/strong>\u5727\u7e2e\u7387\u304c\u4f4e\u3044\u307e\u305f\u306f\u4f4e\u7528\u91cf\u306eAPI\u3002<\/li>\n<li><strong>\u9577\u6240\uff1a<\/strong>\u5f37\u3044\u9846\u7c92\u3001\u512a\u308c\u305f\u6d41\u52d5\u6027\u3001\u5e45\u5e83\u3044\u9069\u7528\u6027\u3002<\/li>\n<li><strong>\u77ed\u6240\uff1a<\/strong>\u3088\u308a\u591a\u304f\u306e\u6642\u9593\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6eb6\u5a92\u6b8b\u57fa\u304c\u53ef\u80fd\u3067\u3059\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignleft size-full wp-image-4378\" src=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/wet-granulation-VS-dry-granulation.png?quality=85&strip=all\" alt=\"\" width=\"624\" height=\"618\" srcset=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/wet-granulation-VS-dry-granulation.png?quality=85&strip=all 624w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/wet-granulation-VS-dry-granulation-300x297.png?quality=85&strip=all 300w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/wet-granulation-VS-dry-granulation-150x150.png?quality=85&strip=all 150w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/08\/wet-granulation-VS-dry-granulation-12x12.png?quality=85&strip=all 12w\" sizes=\"(max-width: 624px) 100vw, 624px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"5_Comparison_Table_of_Pill_Manufacturing_Methods\"><\/span>5\u3002\u4e38\u85ac\u88fd\u9020\u65b9\u6cd5\u306e\u6bd4\u8f03\u8868<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong><b>\u65b9\u6cd5<\/b><\/strong><\/td>\n<td><strong><b>\u30d7\u30ed\u30bb\u30b9\u306e\u8aac\u660e<\/b><\/strong><\/td>\n<td><strong><b>\u306b\u6700\u9069\u3067\u3059<\/b><\/strong><\/td>\n<td><strong><b>\u5229\u70b9<\/b><\/strong><\/td>\n<td><strong><b>\u8ab2\u984c<\/b><\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>\u76f4\u63a5\u5727\u7e2e\uff08DC\uff09<\/strong><\/td>\n<td>API +\u8ce6\u5f62\u5264\u2192\u76f4\u63a5\u5727\u7e2e\u3092\u30d6\u30ec\u30f3\u30c9\u3057\u307e\u3059<\/td>\n<td>\u71b1\/\u6e7f\u6c17\u306b\u654f\u611f\u306aAPI;\u9069\u5207\u306a\u30d1\u30a6\u30c0\u30fc\u30d6\u30ec\u30f3\u30c9<\/td>\n<td>\u9ad8\u901f\u3001\u30b7\u30f3\u30d7\u30eb\u3001\u6eb6\u5264\u306a\u3057\u3001\u5c11\u306a\u3044 <strong>\u30bf\u30d6\u30ec\u30c3\u30c8\u306e\u88fd\u9020\u624b\u9806<\/strong>\u3001\u74b0\u5883\u306b\u512a\u3057\u3044<\/td>\n<td>\u7279\u5225\u306a\u8ce6\u5f62\u5264\u304c\u5fc5\u8981\u3067\u3059\u3002\u3044\u304f\u3064\u304b\u306eAPI\u3067\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u4f4e\u3044<\/td>\n<\/tr>\n<tr>\n<td><strong>\u4e7e\u71e5\u9846\u7c92\uff08dg\uff09<\/strong><\/td>\n<td>\u5727\u7e2e\uff08\u30b9\u30e9\u30c3\u30ae\u30f3\u30b0\/\u30ed\u30fc\u30e9\u30fc\u5727\u7e2e\uff09\u2192\u9846\u7c92\u3078\u306e\u7c89\u7815<\/td>\n<td>\u71b1\/\u6c34\u5206\u306b\u654f\u611f\u306aAPI<\/td>\n<td>\u6eb6\u5264\u306a\u3057\u3001\u8cbb\u7528\u5bfe\u52b9\u679c\u304c\u9ad8\u304f\u3001\u6d41\u308c\u304c\u6539\u5584\u3055\u308c\u307e\u3059<\/td>\n<td>\u5236\u9650\u3055\u308c\u305f\u5727\u7e2e\u7387\u306f\u3001\u7279\u5b9a\u306e\u6a5f\u5668\u304c\u5fc5\u8981\u3067\u3059<\/td>\n<\/tr>\n<tr>\n<td><strong>\u6e7f\u6f64\u9846\u7c92\uff08WG\uff09<\/strong><\/td>\n<td>\u30d0\u30a4\u30f3\u30c0\u30fc\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3 +\u30d1\u30a6\u30c0\u30fc\u2192\u9846\u7c92\u2192\u4e7e\u71e5 +\u30b5\u30a4\u30b8\u30f3\u30b0<\/td>\n<td>\u5727\u7e2e\u7387\u304c\u4f4e\u3044\/\u4f4e\u7528\u91cf\u306eAPI<\/td>\n<td>\u5f37\u3044\u9846\u7c92\u3001\u5747\u4e00\u306a\u5206\u5e03\u3001\u5e45\u5e83\u3044\u9069\u7528\u6027<\/td>\n<td>\u6642\u9593\u304c\u304b\u304b\u308a\u3001\u8cbb\u7528\u304c\u304b\u304b\u308a\u3001\u6eb6\u5264\u51e6\u7406\u304c\u5fc5\u8981\u3067\u3059<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u533b\u85ac\u54c1\u306e\u9320\u5264\u88fd\u9020\u3067\u306f\u30013\u3064\u306e\u4e3b\u8981\u306a\u65b9\u6cd5\u304c\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <strong>\u76f4\u63a5\u5727\u7e2e\uff08DC\uff09<\/strong>, <strong>\u4e7e\u71e5\u9846\u7c92\uff08dg\uff09<\/strong>\u3001 \u305d\u3057\u3066 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