{"id":5030,"date":"2026-02-06T14:33:10","date_gmt":"2026-02-06T06:33:10","guid":{"rendered":"https:\/\/www.jianpaitech.com\/?post_type=blog&#038;p=5030"},"modified":"2026-02-06T14:33:10","modified_gmt":"2026-02-06T06:33:10","slug":"high-shear-mixer-granulation-how-to-determine-the-perfect-end-point","status":"publish","type":"blog","link":"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/","title":{"rendered":"Granulation avec m\u00e9langeur \u00e0 cisaillement \u00e9lev\u00e9\u00a0: comment d\u00e9terminer le point final parfait\u00a0?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table des mati\u00e8res<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table des mati\u00e8res\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Basculer<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Introduction\" >Introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#What_is_the_Granulation_End-Point\" >Quel est le point final de la granulation\u00a0?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Why_is_the_Granulation_End-Point_So_Critical\" >Pourquoi le point final de la granulation est-il si critique\u00a0?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Key_Variables_Influencing_the_End-Point\" >Variables cl\u00e9s influen\u00e7ant le point final<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#4_Practical_Methods_to_Determine_the_End-Point_Comparison\" >4 m\u00e9thodes pratiques pour d\u00e9terminer le point final (comparaison)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#The_Traditional_Approach_Time_Manual_Squeeze\" >L'approche traditionnelle\u00a0: compression temporelle et manuelle<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Power_Consumption_Amperage_The_Industry_Standard\" >Consommation d'\u00e9nergie\/amp\u00e9rage (la norme de l'industrie)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Torque_Monitoring_The_Precision_Choice\" >Surveillance du couple (le choix de pr\u00e9cision)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Advanced_Process_Analytical_Technology_PAT\" >Technologie analytique avanc\u00e9e des processus (PAT)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Comparison_Table_Which_Method_Fits_Your_Production\" >Tableau comparatif\u00a0: quelle m\u00e9thode convient \u00e0 votre production\u00a0?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#How_Jianpais_Rapid_Mixer_Granulator_Ensures_Consistency\" >Comment le granulateur m\u00e9langeur rapide de Jianpai garantit la coh\u00e9rence<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.jianpaitech.com\/fr\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Introduction\"><\/span><span class=\"ng-star-inserted\">Introduction<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Dans la fabrication pharmaceutique, la coh\u00e9rence est reine. Lors de la production de comprim\u00e9s, le\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/fr\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulation du m\u00e9langeur \u00e0 cisaillement \u00e9lev\u00e9<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0Le processus est souvent l\u2019\u00e9tape la plus critique. Il d\u00e9termine la fluidit\u00e9, la compressibilit\u00e9 et le profil de dissolution de votre forme posologique finale.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Cependant, une question taraude aussi bien les op\u00e9rateurs que les scientifiques en formulation\u00a0:\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">\u00ab Quand exactement la granulation est-elle termin\u00e9e ?<\/span><\/strong><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Arr\u00eatez-vous trop t\u00f4t et vous aurez des amendes qui ne se compresseront pas. Arr\u00eatez-vous trop tard et vous aurez des grumeaux durs et surdimensionn\u00e9s qui ne se dissoudront pas. Ce \u00ab point id\u00e9al \u00bb est appel\u00e9 le\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Point final de granulation<\/span><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Dans ce guide, nous irons au-del\u00e0 des conjectures. Nous explorerons la science derri\u00e8re la d\u00e9tection des points finaux et comparerons les m\u00e9thodes traditionnelles aux technologies modernes utilis\u00e9es dans les technologies avanc\u00e9es de Jianpai.\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/fr\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulateur m\u00e9langeur rapide<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0(RMG).<\/span><\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft size-full wp-image-4638\" src=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator.jpg?quality=85&strip=all\" alt=\"\" width=\"675\" height=\"408\" srcset=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator.jpg?quality=85&strip=all 675w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator-300x181.jpg?quality=85&strip=all 300w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator-18x12.jpg?quality=85&strip=all 18w\" sizes=\"(max-width: 675px) 100vw, 675px\" \/><\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"What_is_the_Granulation_End-Point\"><\/span><span class=\"ng-star-inserted\">Quel est le point final de la granulation\u00a0?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Le\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Point final de granulation<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0est le moment pr\u00e9cis de la phase de m\u00e9lange humide o\u00f9 les granul\u00e9s ont atteint les propri\u00e9t\u00e9s souhait\u00e9es :<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Distribution granulom\u00e9trique cible\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Ni trop poussi\u00e9reux, ni trop grumeleux.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Densit\u00e9 optimale\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Assure un remplissage uniforme de la matrice dans la presse \u00e0 comprim\u00e9s.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Porosit\u00e9 correcte\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Affecte la distribution du liant et la r\u00e9sistance des granul\u00e9s.<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Dans un\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/fr\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Machine de granulation humide<\/span><\/a><\/strong><span class=\"ng-star-inserted\">, ce moment se produit lorsque le liant liquide a compl\u00e8tement mouill\u00e9 la poudre et form\u00e9 des ponts solides, mais avant que les granul\u00e9s ne deviennent une p\u00e2te inutilisable.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Why_is_the_Granulation_End-Point_So_Critical\"><\/span><span class=\"ng-star-inserted\">Pourquoi le point final de la granulation est-il si critique\u00a0?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Manquer le point final a un effet domino sur l\u2019ensemble de votre cha\u00eene de production\u00a0:<\/span><\/p>\n<ol class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">D\u00e9fauts de la tablette\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Un mouillage excessif entra\u00eene un \u00ab ramassage \u00bb et un \u00ab collage \u00bb sur le poin\u00e7on de la presse \u00e0 comprim\u00e9s.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">\u00c9chec de la dissolution\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Les particules dures et trop granul\u00e9es peuvent \u00e9chouer aux tests de dissolution au QC.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Perte de rendement\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Les lots sous-granul\u00e9s g\u00e9n\u00e8rent des fines excessives, qui sont gaspill\u00e9es dans le\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/fr\/product_category\/fluid-bed-dryer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">S\u00e9cheur \u00e0 lit fluidis\u00e9<\/span><\/a><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Variabilit\u00e9 d'un lot \u00e0 l'autre\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Si l'op\u00e9rateur A s'arr\u00eate \u00e0 3 minutes et l'op\u00e9rateur B s'arr\u00eate \u00e0 4 minutes, vous obtenez deux produits diff\u00e9rents.<\/span><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Key_Variables_Influencing_the_End-Point\"><\/span><span class=\"ng-star-inserted\">Variables cl\u00e9s influen\u00e7ant le point final<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Avant de choisir une m\u00e9thode de d\u00e9tection, comprenez que le point final est une cible mobile influenc\u00e9e par\u00a0:<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Taux d\u2019ajout de liant\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Une pulv\u00e9risation trop rapide provoque un mouillage excessif local.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Vitesse de la turbine\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Des vitesses plus \u00e9lev\u00e9es ajoutent plus d\u2019\u00e9nergie m\u00e9canique, atteignant le point final plus rapidement.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Variabilit\u00e9 des mati\u00e8res premi\u00e8res\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Un l\u00e9ger changement dans la taille des particules de votre API ou de vos excipients peut modifier le temps de m\u00e9lange requis.<\/span><\/p>\n<\/li>\n<\/ul>\n<blockquote class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Conseil de pro\u00a0:\u00a0un robuste\u00a0<strong class=\"ng-star-inserted\">Processus de granulation \u00e0 cisaillement \u00e9lev\u00e9<\/strong>\u00a0repose sur le contr\u00f4le de ces variables via un syst\u00e8me de gestion de recettes PLC, une fonctionnalit\u00e9 standard des RMG Jianpai.<\/span><\/p>\n<p>&nbsp;<\/p><\/blockquote>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"4_Practical_Methods_to_Determine_the_End-Point_Comparison\"><\/span><span class=\"ng-star-inserted\">4 m\u00e9thodes pratiques pour d\u00e9terminer le point final (comparaison)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Comment savoir quand s\u2019arr\u00eater ? Voici les quatre m\u00e9thodes les plus couramment utilis\u00e9es dans l\u2019industrie, class\u00e9es de base \u00e0 avanc\u00e9e.<\/span><\/p>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"The_Traditional_Approach_Time_Manual_Squeeze\"><\/span><span class=\"ng-star-inserted\">L'approche traditionnelle\u00a0: compression temporelle et manuelle<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9thode:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Faites fonctionner le m\u00e9langeur pendant une dur\u00e9e d\u00e9termin\u00e9e (par exemple 5 minutes), puis arr\u00eatez-vous. L'op\u00e9rateur ouvre le couvercle, prend une poign\u00e9e de granul\u00e9s et les presse (le \u00ab Test Banane \u00bb). S\u2019il conserve sa forme mais se brise sous la pression du pouce, c\u2019est fait.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Avantages:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Co\u00fbt nul\u00a0; aucune technologie n'est n\u00e9cessaire.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Inconv\u00e9nients:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Tr\u00e8s subjectif. La \u00ab pression de l\u2019op\u00e9rateur A \u00bb est diff\u00e9rente de la \u00ab pression de l\u2019op\u00e9rateur B \u00bb. Non conforme aux BPF pour les m\u00e9dicaments critiques.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Power_Consumption_Amperage_The_Industry_Standard\"><\/span><span class=\"ng-star-inserted\">Consommation d'\u00e9nergie\/amp\u00e9rage (la norme de l'industrie)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9thode:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0\u00c0 mesure que les granules se forment et se densifient, la r\u00e9sistance sur les pales de la turbine augmente. Cela impose une charge plus \u00e9lev\u00e9e au moteur, provoquant\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Amp\u00e9rage (Amp\u00e8re)<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0lire pour piquer. Vous d\u00e9finissez une limite d'amp\u00e8re cible (par exemple, arr\u00eatez-vous lorsque le moteur atteint 25 amp\u00e8res).<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Avantages:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Peu co\u00fbteux \u00e0 mettre en \u0153uvre\u00a0; largement compris.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Inconv\u00e9nients:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0L'efficacit\u00e9 du moteur, la tension de la courroie et l'usure des engrenages peuvent affecter les lectures d'amp\u00e8re. Il mesure le\u00a0<\/span><span class=\"ng-star-inserted\">moteur<\/span><span class=\"ng-star-inserted\">\u00a0l'effort, pas le\u00a0<\/span><span class=\"ng-star-inserted\">granul\u00e9s<\/span><span class=\"ng-star-inserted\">\u00a0Etat directement.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Torque_Monitoring_The_Precision_Choice\"><\/span><span class=\"ng-star-inserted\">Surveillance du couple (le choix de pr\u00e9cision)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9thode:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Ceci mesure le r\u00e9el\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Couple (Nm)<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0exerc\u00e9e sur l\u2019arbre de la roue.<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Couple indirect\u00a0:<\/span><span class=\"ng-star-inserted\">\u00a0Calcul\u00e9 \u00e0 partir du courant du variateur VFD.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Couple direct\u00a0:<\/span><span class=\"ng-star-inserted\">\u00a0Mesur\u00e9 via un capteur \u00e0 jauge de contrainte directement sur l'arbre.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Avantages:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Beaucoup plus sensible que l'amp\u00e9rage. Cela est directement li\u00e9 \u00e0 la densit\u00e9 et \u00e0 la rh\u00e9ologie des granules.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Inconv\u00e9nients:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Les capteurs de couple directs sont chers. Le couple indirect (calcul\u00e9) est un bon \u00e9quilibre pour la plupart\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granulation du RMG<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0processus.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Advanced_Process_Analytical_Technology_PAT\"><\/span><span class=\"ng-star-inserted\">Technologie analytique avanc\u00e9e des processus (PAT)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9thode:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Utilisation de capteurs d'\u00e9mission acoustique (\u00e9coute du bruit des granul\u00e9s frappant le mur) ou de sondes NIR (proche infrarouge) pour mesurer l'humidit\u00e9 en temps r\u00e9el.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Avantages:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Le \u00ab Saint Graal \u00bb de la pr\u00e9cision.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Inconv\u00e9nients:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Extr\u00eamement cher\u00a0; difficile \u00e0 calibrer et \u00e0 valider.<\/span><\/p>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Comparison_Table_Which_Method_Fits_Your_Production\"><\/span><span class=\"ng-star-inserted\">Tableau comparatif\u00a0: quelle m\u00e9thode convient \u00e0 votre production\u00a0?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"table-container ng-star-inserted\">\n<table>\n<tbody>\n<tr class=\"table-header ng-star-inserted\">\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9thode<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pr\u00e9cision<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Co\u00fbt<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Conformit\u00e9 aux BPF<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Id\u00e9al pour\u2026<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pressage manuel<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Faible<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Faible<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pauvre<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">R&amp;D, produits alimentaires simples<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Bas\u00e9 sur le temps<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Moyen<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Faible<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Mod\u00e9r\u00e9<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Des processus valid\u00e9s et stables<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Puissance (amp\u00e8res)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Haut<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Moyen<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Bien<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pharmaceutique g\u00e9n\u00e9rique standard<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Couple (Nm)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Tr\u00e8s \u00e9lev\u00e9<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Haut<\/span><\/td>\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Excellent<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9dicaments complexes\/puissants<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">PAT (NIR\/Acoustique)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Extr\u00eame<\/span><\/td>\n<td class=\"ng-star-inserted\">\n<pre><code class=\"rendered\"><\/code><\/pre>\n<\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Excellent<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Nouveaux m\u00e9dicaments de grande valeur<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<\/div>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"How_Jianpais_Rapid_Mixer_Granulator_Ensures_Consistency\"><\/span><span class=\"ng-star-inserted\">Comment le granulateur m\u00e9langeur rapide de Jianpai garantit la coh\u00e9rence<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">\u00c0\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Jianpai<\/span><\/strong><span class=\"ng-star-inserted\">, nous comprenons que la reproductibilit\u00e9 est le plus grand d\u00e9fi dans\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granulation du m\u00e9langeur \u00e0 cisaillement \u00e9lev\u00e9<\/span><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Notre\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/fr\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulateur m\u00e9langeur rapide<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0La s\u00e9rie est con\u00e7ue pour \u00e9liminer le \u00ab facteur humain \u00bb\u00a0:<\/span><\/p>\n<ol class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Logique \u00e0 double contr\u00f4le\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Notre automate Siemens vous permet de d\u00e9finir le point final en fonction de\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Temps OU Puissance\/Couple<\/span><\/strong><span class=\"ng-star-inserted\">. Par exemple:\u00a0<\/span><span class=\"ng-star-inserted\">\"M\u00e9langer pendant 3 minutes ET jusqu'\u00e0 ce que le couple atteigne 15 Nm.\"<\/span><span class=\"ng-star-inserted\">\u00a0Cette logique \u00ab ET \u00bb assure la s\u00e9curit\u00e9.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Tendances en temps r\u00e9el\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0L'IHM affiche un graphique en direct de la consommation Puissance\/Couple, permettant aux scientifiques en formulation de visualiser les phases de granulation (mouillage -&gt; nucl\u00e9ation -&gt; plateau).<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">G\u00e9om\u00e9trie \u00e9volutive\u00a0:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Nous veillons \u00e0 ce que la corr\u00e9lation entre le couple et la qualit\u00e9 des granul\u00e9s reste coh\u00e9rente, de nos mod\u00e8les de R&amp;D en laboratoire \u00e0 nos mod\u00e8les de production.<\/span><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span><span class=\"ng-star-inserted\">Conclusion<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">D\u00e9terminer le\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Point final de granulation<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0n'est plus un jeu de devinettes. Alors que la m\u00e9thode \u00ab\u00a0Hand Squeeze\u00a0\u00bb nous a bien servi dans le pass\u00e9, les normes GMP modernes exigent des d\u00e9cisions bas\u00e9es sur les donn\u00e9es.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pour la plupart des fabricants de produits pharmaceutiques,\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Consommation d'\u00e9nergie (amp\u00e9rage) ou surveillance du couple<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0offre le meilleur \u00e9quilibre entre pr\u00e9cision et co\u00fbt. En investissant dans un\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/fr\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Machine de granulation humide<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0\u00e9quip\u00e9 de syst\u00e8mes de surveillance avanc\u00e9s, vous garantissez que chaque lot est parfaitement compress\u00e9 en comprim\u00e9s de haute qualit\u00e9.<\/span><\/p>\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pr\u00eat \u00e0 mettre \u00e0 niveau votre processus de granulation\u00a0?<\/span><\/strong><br class=\"ng-star-inserted\" \/><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contacter Jianpai<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0aujourd'hui pour discuter de notre intelligence\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granulateurs m\u00e9langeurs rapides<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0et comment ils peuvent r\u00e9soudre vos probl\u00e8mes d'incoh\u00e9rence de lots.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Introduction Dans la fabrication pharmaceutique, la coh\u00e9rence est reine. Lors de la production de comprim\u00e9s, le processus de granulation avec m\u00e9langeur \u00e0 cisaillement \u00e9lev\u00e9 est souvent l'\u00e9tape la plus critique. Il d\u00e9termine la fluidit\u00e9, la compressibilit\u00e9 et le profil de dissolution de votre forme posologique finale. Cependant, une question taraude aussi bien les op\u00e9rateurs que les scientifiques en formulation\u00a0: \"Quand exactement la granulation est-elle termin\u00e9e\u00a0?\" Arr\u00eatez-vous trop t\u00f4t et vous aurez des amendes qui [\u2026]<\/p>","protected":false},"featured_media":5031,"template":"","meta":{"_acf_changed":false,"footnotes":""},"blog_category":[16],"class_list":["post-5030","blog","type-blog","status-publish","has-post-thumbnail","hentry","blog_category-industry-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/blog\/5030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/types\/blog"}],"version-history":[{"count":1,"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/blog\/5030\/revisions"}],"predecessor-version":[{"id":5032,"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/blog\/5030\/revisions\/5032"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/media\/5031"}],"wp:attachment":[{"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/media?parent=5030"}],"wp:term":[{"taxonomy":"blog_category","embeddable":true,"href":"https:\/\/www.jianpaitech.com\/fr\/wp-json\/wp\/v2\/blog_category?post=5030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}