{"id":5030,"date":"2026-02-06T14:33:10","date_gmt":"2026-02-06T06:33:10","guid":{"rendered":"https:\/\/www.jianpaitech.com\/?post_type=blog&#038;p=5030"},"modified":"2026-02-06T14:33:10","modified_gmt":"2026-02-06T06:33:10","slug":"high-shear-mixer-granulation-how-to-determine-the-perfect-end-point","status":"publish","type":"blog","link":"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/","title":{"rendered":"Granulaci\u00f3n con mezclador de alto cizallamiento: \u00bfC\u00f3mo determinar el punto final perfecto?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Tabla de contenido<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabla de contenidos\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Palanca<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Introduction\" >Introducci\u00f3n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#What_is_the_Granulation_End-Point\" >\u00bfCu\u00e1l es el punto final de granulaci\u00f3n?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Why_is_the_Granulation_End-Point_So_Critical\" >\u00bfPor qu\u00e9 es tan cr\u00edtico el punto final de la granulaci\u00f3n?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Key_Variables_Influencing_the_End-Point\" >Variables clave que influyen en el punto final<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#4_Practical_Methods_to_Determine_the_End-Point_Comparison\" >4 m\u00e9todos pr\u00e1cticos para determinar el punto final (comparaci\u00f3n)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#The_Traditional_Approach_Time_Manual_Squeeze\" >El enfoque tradicional: tiempo y compresi\u00f3n manual<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Power_Consumption_Amperage_The_Industry_Standard\" >Consumo de energ\u00eda\/amperaje (el est\u00e1ndar de la industria)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Torque_Monitoring_The_Precision_Choice\" >Monitoreo de torque (la elecci\u00f3n de precisi\u00f3n)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Advanced_Process_Analytical_Technology_PAT\" >Tecnolog\u00eda anal\u00edtica de procesos avanzada (PAT)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Comparison_Table_Which_Method_Fits_Your_Production\" >Tabla comparativa: \u00bfQu\u00e9 m\u00e9todo se adapta a su producci\u00f3n?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#How_Jianpais_Rapid_Mixer_Granulator_Ensures_Consistency\" >C\u00f3mo el granulador mezclador r\u00e1pido de Jianpai garantiza la consistencia<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.jianpaitech.com\/es\/blog\/high-shear-mixer-granulation-how-to-determine-the-perfect-end-point\/#Conclusion\" >Conclusi\u00f3n<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Introduction\"><\/span><span class=\"ng-star-inserted\">Introducci\u00f3n<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">En la fabricaci\u00f3n farmac\u00e9utica, la coherencia es la clave. Al producir tabletas, el\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/es\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulaci\u00f3n con mezclador de alto cizallamiento<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0El proceso es a menudo el paso m\u00e1s cr\u00edtico. Determina el perfil de fluidez, compresibilidad y disoluci\u00f3n de su forma farmac\u00e9utica final.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Sin embargo, una pregunta preocupa tanto a los operadores como a los cient\u00edficos de formulaci\u00f3n:\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">\u201c\u00bfCu\u00e1ndo termina exactamente la granulaci\u00f3n?\u201d<\/span><\/strong><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Si se detiene demasiado pronto, tendr\u00e1 multas que no se reducir\u00e1n. Si dejas de hacerlo demasiado tarde, tendr\u00e1s grumos duros y de gran tama\u00f1o que no se disolver\u00e1n. Este \"punto \u00f3ptimo\" se llama\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Punto final de granulaci\u00f3n<\/span><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">En esta gu\u00eda, iremos m\u00e1s all\u00e1 de las conjeturas. Exploraremos la ciencia detr\u00e1s de la detecci\u00f3n de puntos finales y compararemos los m\u00e9todos tradicionales con las tecnolog\u00edas modernas utilizadas en las tecnolog\u00edas avanzadas de Jianpai.\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/es\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulador mezclador r\u00e1pido<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0(RMG).<\/span><\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft size-full wp-image-4638\" src=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator.jpg?quality=85&strip=all\" alt=\"\" width=\"675\" height=\"408\" srcset=\"https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator.jpg?quality=85&strip=all 675w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator-300x181.jpg?quality=85&strip=all 300w, https:\/\/i1.wp.com\/www.jianpaitech.com\/wp-content\/uploads\/2025\/11\/Model-JHZ-D-Series-High-efficient-Wet-process-Granulator-18x12.jpg?quality=85&strip=all 18w\" sizes=\"(max-width: 675px) 100vw, 675px\" \/><\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"What_is_the_Granulation_End-Point\"><\/span><span class=\"ng-star-inserted\">\u00bfCu\u00e1l es el punto final de granulaci\u00f3n?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">El\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Punto final de granulaci\u00f3n<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0es el momento preciso durante la fase de mezcla h\u00fameda en el que los gr\u00e1nulos han alcanzado las propiedades deseadas:<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Distribuci\u00f3n del tama\u00f1o de part\u00edcula objetivo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Ni demasiado polvoriento ni demasiado grumoso.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Densidad \u00f3ptima:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Garantiza un llenado uniforme del troquel en la prensa de tabletas.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Porosidad correcta:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Afecta la distribuci\u00f3n del aglutinante y la resistencia de los gr\u00e1nulos.<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">en un\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/es\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">M\u00e1quina granuladora h\u00fameda<\/span><\/a><\/strong><span class=\"ng-star-inserted\">, este momento se produce cuando el aglutinante l\u00edquido ha humedecido completamente el polvo y formado puentes s\u00f3lidos, pero antes de que los gr\u00e1nulos se conviertan en una pasta inutilizable.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Why_is_the_Granulation_End-Point_So_Critical\"><\/span><span class=\"ng-star-inserted\">\u00bfPor qu\u00e9 es tan cr\u00edtico el punto final de la granulaci\u00f3n?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">No alcanzar el punto final tiene un efecto domin\u00f3 en toda su l\u00ednea de producci\u00f3n:<\/span><\/p>\n<ol class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Defectos de la tableta:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0La humectaci\u00f3n excesiva provoca que se \u201cpellizque\u201d y se \u201cpegue\u201d el punz\u00f3n de la prensa para tabletas.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Fallo de disoluci\u00f3n:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Las part\u00edculas duras y demasiado granuladas pueden no superar las pruebas de disoluci\u00f3n en el control de calidad.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">P\u00e9rdida de rendimiento:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Los lotes poco granulados generan finos excesivos, que se desperdician en el\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/es\/product_category\/fluid-bed-dryer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Secador de lecho fluido<\/span><\/a><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Variabilidad de lote a lote:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Si el Operador A se detiene a los 3 minutos y el Operador B se detiene a los 4 minutos, obtienes dos productos diferentes.<\/span><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Key_Variables_Influencing_the_End-Point\"><\/span><span class=\"ng-star-inserted\">Variables clave que influyen en el punto final<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Antes de elegir un m\u00e9todo de detecci\u00f3n, comprenda que el punto final es un objetivo en movimiento influenciado por:<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Tasa de adici\u00f3n de aglutinante:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Pulverizar demasiado r\u00e1pido provoca un exceso de humedecimiento local.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Velocidad del impulsor:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Las velocidades m\u00e1s altas a\u00f1aden m\u00e1s energ\u00eda mec\u00e1nica, alcanzando el punto final m\u00e1s r\u00e1pido.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Variabilidad de la materia prima:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Un ligero cambio en el tama\u00f1o de las part\u00edculas de su API o excipientes puede cambiar el tiempo de mezcla requerido.<\/span><\/p>\n<\/li>\n<\/ul>\n<blockquote class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Consejo profesional: un robusto\u00a0<strong class=\"ng-star-inserted\">Proceso de granulaci\u00f3n de alto cizallamiento<\/strong>\u00a0se basa en el control de estas variables a trav\u00e9s de un sistema de gesti\u00f3n de recetas PLC, una caracter\u00edstica est\u00e1ndar en los Jianpai RMG.<\/span><\/p>\n<p>&nbsp;<\/p><\/blockquote>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"4_Practical_Methods_to_Determine_the_End-Point_Comparison\"><\/span><span class=\"ng-star-inserted\">4 m\u00e9todos pr\u00e1cticos para determinar el punto final (comparaci\u00f3n)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">\u00bfC\u00f3mo sabes cu\u00e1ndo parar? A continuaci\u00f3n se muestran los cuatro m\u00e9todos m\u00e1s comunes utilizados en la industria, clasificados desde b\u00e1sico hasta avanzado.<\/span><\/p>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"The_Traditional_Approach_Time_Manual_Squeeze\"><\/span><span class=\"ng-star-inserted\">El enfoque tradicional: tiempo y compresi\u00f3n manual<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Haga funcionar la batidora durante un tiempo fijo (por ejemplo, 5 minutos) y luego det\u00e9ngala. El operador abre la tapa, toma un pu\u00f1ado de gr\u00e1nulos y los aprieta (la \u201cPrueba del pl\u00e1tano\u201d). Si mantiene la forma pero se rompe con la presi\u00f3n del pulgar, ya est\u00e1.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pros:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Costo cero; no se necesita tecnolog\u00eda.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Altamente subjetivo. El \u201capret\u00f3n del operador A\u201d es diferente del \u201capriete del operador B\u201d. No cumple con GMP para medicamentos cr\u00edticos.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Power_Consumption_Amperage_The_Industry_Standard\"><\/span><span class=\"ng-star-inserted\">Consumo de energ\u00eda\/amperaje (el est\u00e1ndar de la industria)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0A medida que los gr\u00e1nulos se forman y se densifican, aumenta la resistencia de las palas del impulsor. Esto pone una mayor carga en el motor, causando que el\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Amperaje (amperio)<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0leyendo para disparar. Usted establece un l\u00edmite de amperios objetivo (por ejemplo, se detiene cuando el motor alcanza los 25 amperios).<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pros:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Barato de implementar; ampliamente entendido.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0La eficiencia del motor, la tensi\u00f3n de la correa y el desgaste de los engranajes pueden afectar las lecturas de amperios. Mide el\u00a0<\/span><span class=\"ng-star-inserted\">motor<\/span><span class=\"ng-star-inserted\">\u00a0esfuerzo, no el\u00a0<\/span><span class=\"ng-star-inserted\">gr\u00e1nulos<\/span><span class=\"ng-star-inserted\">\u00a0estado directamente.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Torque_Monitoring_The_Precision_Choice\"><\/span><span class=\"ng-star-inserted\">Monitoreo de torque (la elecci\u00f3n de precisi\u00f3n)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Esto mide el real\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Par (Nm)<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0ejercida sobre el eje del impulsor.<\/span><\/p>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Torque indirecto:<\/span><span class=\"ng-star-inserted\">\u00a0Calculado a partir de la corriente del variador VFD.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Torque directo:<\/span><span class=\"ng-star-inserted\">\u00a0Medido mediante un sensor extens\u00edmetro directamente en el eje.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pros:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Mucho m\u00e1s sensible que Amperage. Se correlaciona directamente con la densidad de los gr\u00e1nulos y la reolog\u00eda.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Los sensores de par directo son caros. El par indirecto (calculado) es un buen equilibrio para la mayor\u00eda\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granulaci\u00f3n RMG<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0procesos.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Advanced_Process_Analytical_Technology_PAT\"><\/span><span class=\"ng-star-inserted\">Tecnolog\u00eda anal\u00edtica de procesos avanzada (PAT)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Utilizando sensores de emisi\u00f3n ac\u00fastica (escuchando el sonido de los gr\u00e1nulos golpeando la pared) o sondas NIR (infrarrojos cercanos) para medir la humedad en tiempo real.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pros:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0El \u201cSanto Grial\u201d de la precisi\u00f3n.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contras:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Extremadamente caro; dif\u00edcil de calibrar y validar.<\/span><\/p>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Comparison_Table_Which_Method_Fits_Your_Production\"><\/span><span class=\"ng-star-inserted\">Tabla comparativa: \u00bfQu\u00e9 m\u00e9todo se adapta a su producci\u00f3n?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"table-container ng-star-inserted\">\n<table>\n<tbody>\n<tr class=\"table-header ng-star-inserted\">\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">M\u00e9todo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Exactitud<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Costo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Cumplimiento de GMP<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Lo mejor para\u2026<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Apret\u00f3n manual<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Bajo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Bajo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Pobre<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">I+D, productos alimenticios sencillos<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Basado en el tiempo<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Medio<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Bajo<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Moderado<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Procesos validados y estables.<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Potencia (Amperios)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Alto<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Medio<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Bien<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Farmac\u00e9utica gen\u00e9rica est\u00e1ndar<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Par (Nm)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">muy alto<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Alto<\/span><\/td>\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Excelente<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Medicamentos complejos\/potentes<\/span><\/td>\n<\/tr>\n<tr class=\"ng-star-inserted\">\n<td class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">PAT (NIR\/Ac\u00fastica)<\/span><\/strong><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Extremo<\/span><\/td>\n<td class=\"ng-star-inserted\">\n<pre><code class=\"rendered\"><\/code><\/pre>\n<\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Excelente<\/span><\/td>\n<td class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Nuevos medicamentos de alto valor<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<\/div>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"How_Jianpais_Rapid_Mixer_Granulator_Ensures_Consistency\"><\/span><span class=\"ng-star-inserted\">C\u00f3mo el granulador mezclador r\u00e1pido de Jianpai garantiza la consistencia<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">En\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Jianpai<\/span><\/strong><span class=\"ng-star-inserted\">, entendemos que la reproducibilidad es el mayor desaf\u00edo en\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granulaci\u00f3n con mezclador de alto cizallamiento<\/span><\/strong><span class=\"ng-star-inserted\">.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Nuestro\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/es\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">Granulador mezclador r\u00e1pido<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0La serie est\u00e1 dise\u00f1ada para eliminar el \u201cfactor humano\u201d:<\/span><\/p>\n<ol class=\"ng-star-inserted\">\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">L\u00f3gica de control dual:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Nuestro PLC Siemens le permite configurar el punto final en funci\u00f3n de\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Tiempo O potencia\/par<\/span><\/strong><span class=\"ng-star-inserted\">. Por ejemplo:\u00a0<\/span><span class=\"ng-star-inserted\">\"Mezclar durante 3 minutos Y hasta que el par alcance 15 Nm\".<\/span><span class=\"ng-star-inserted\">\u00a0Esta l\u00f3gica \"Y\" garantiza la seguridad.<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Tendencias en tiempo real:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0La HMI muestra un gr\u00e1fico en vivo del consumo de potencia\/par, lo que permite a los cient\u00edficos de formulaci\u00f3n visualizar las fases de granulaci\u00f3n (humectaci\u00f3n -&gt; nucleaci\u00f3n -&gt; meseta).<\/span><\/p>\n<\/li>\n<li class=\"ng-star-inserted\">\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Geometr\u00eda escalable:<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Nos aseguramos de que la correlaci\u00f3n entre el par y la calidad de los gr\u00e1nulos se mantenga constante desde nuestros modelos de I+D de laboratorio hasta nuestros modelos de producci\u00f3n.<\/span><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2 class=\"ng-star-inserted\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span><span class=\"ng-star-inserted\">Conclusi\u00f3n<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Determinando el\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Punto final de granulaci\u00f3n<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0Ya no es un juego de adivinanzas. Si bien el m\u00e9todo \u201cHand Squeeze\u201d nos sirvi\u00f3 bien en el pasado, los est\u00e1ndares GMP modernos exigen decisiones basadas en datos.<\/span><\/p>\n<p class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Para la mayor\u00eda de los fabricantes farmac\u00e9uticos,\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Consumo de energ\u00eda (amperaje) o monitoreo de par<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0ofrece el mejor equilibrio entre precisi\u00f3n y costo. Al invertir en un\u00a0<\/span><strong class=\"ng-star-inserted\"><a class=\"ng-star-inserted\" href=\"https:\/\/www.jianpaitech.com\/es\/product_category\/high-shear-mixer\/\" target=\"_blank\" rel=\"noopener\"><span class=\"ng-star-inserted\">M\u00e1quina granuladora h\u00fameda<\/span><\/a><\/strong><span class=\"ng-star-inserted\">\u00a0Equipado con sistemas de monitoreo avanzados, se asegura de que cada lote se comprima perfectamente en tabletas de alta calidad.<\/span><\/p>\n<p class=\"ng-star-inserted\"><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">\u00bfListo para actualizar su proceso de granulaci\u00f3n?<\/span><\/strong><br class=\"ng-star-inserted\" \/><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Contacto jianpai<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0hoy para discutir nuestra inteligencia\u00a0<\/span><strong class=\"ng-star-inserted\"><span class=\"ng-star-inserted\">Granuladores mezcladores r\u00e1pidos<\/span><\/strong><span class=\"ng-star-inserted\">\u00a0y c\u00f3mo pueden resolver sus problemas de inconsistencia de lotes.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n En la fabricaci\u00f3n farmac\u00e9utica, la coherencia es la clave. Al producir tabletas, el proceso de granulaci\u00f3n con mezclador de alto cizallamiento suele ser el paso m\u00e1s cr\u00edtico. Determina el perfil de fluidez, compresibilidad y disoluci\u00f3n de su forma farmac\u00e9utica final. Sin embargo, una pregunta atormenta tanto a los operadores como a los cient\u00edficos de formulaci\u00f3n: \"\u00bfCu\u00e1ndo termina exactamente la granulaci\u00f3n?\" Det\u00e9ngase demasiado pronto y tendr\u00e1 multas que [\u2026]<\/p>","protected":false},"featured_media":5031,"template":"","meta":{"_acf_changed":false,"footnotes":""},"blog_category":[16],"class_list":["post-5030","blog","type-blog","status-publish","has-post-thumbnail","hentry","blog_category-industry-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/blog\/5030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/types\/blog"}],"version-history":[{"count":1,"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/blog\/5030\/revisions"}],"predecessor-version":[{"id":5032,"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/blog\/5030\/revisions\/5032"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/media\/5031"}],"wp:attachment":[{"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/media?parent=5030"}],"wp:term":[{"taxonomy":"blog_category","embeddable":true,"href":"https:\/\/www.jianpaitech.com\/es\/wp-json\/wp\/v2\/blog_category?post=5030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}